GJB2 and Hyperkeratosis: Keratitis-Ichthyosis-Deafness (KID) syndrome is a rare keratinization disorder due to missense mutation of the GJB2 gene (connexin 26) or, rarely, GJB6 (connexin 30).1, 2, 3, 4, 5 Clinical features include ichthyosiform scaling, palmoplantar hyperkeratosis, stippled keratoderma, alopecia along with bilateral hearing loss, and keratitis with corneal neovascularization.1, 2, 3, 4, 5 All changes may not be seen at a time; it takes time to appear at or before puberty.1