Other studies used obesity-dependent models of type 2 DM that derived from a mutation of the gene encoding leptin (ZDF rats) or its receptor (db/db mice), whose normal function precludes obesity by regulating food intake, glucose homeostasis and energy expenditure (Marwarha and Ghribi, 2012; Forny-Germano et al., 2019). The gene discussed is LEP; the disease is Obesity.