Furthermore, hippocampal BACE1 elevation also occurs along with cognitive impairment in an intracerebroventricular (ICV) STZ-injected mice (Santos et al., 2015), which reproduce features of sporadic AD including deficits in brain insulin signaling and energy metabolism, tau hyperphosphorylation, inflammation, neurodegeneration, among many others. Here, BACE1 is linked to Alzheimer disease.