In preeclampsia, PCSK9 expression has also been reported to decrease relative to controls, most prominently in early-onset disease (PE vs. CTRL, median: 0.2 vs. 0.9, p = 0.010; PE vs. LP, median: 0.2 vs. 1.2, p = 0.012) (Mennitti et al., 2024). This evidence concerns the gene PCSK9 and preeclampsia.