However, the formation of fusion transcripts can also occur through transcription-mediated chimerism, which is detectable at the RNA rather than at the DNA level.3, 4, 5 The chimeric RNA PPP1R1B-STARD3 is generated through post-transcriptional splicing of two adjacent genes, namely the upstream PPP1R1B and the downstream STARD3. 6The presence of gene fusions is associated with the leukemogenesis of AML and contributes to the heterogeneity of clinical characteristics and outcomes. The gene discussed is STARD3; the disease is acute myeloid leukemia.