Genetic analysis of neurodegenerative diseases such as ALS, frontotemporal dementia (FTD) (42), Welander distal myopathy (WDM) (43, 44), and multisystem proteinopathies (MSPs) (45, 46) has revealed that TIA-1 carries disease-associated mutations in its IDP region, the prion-like domain (PLD). This evidence concerns the gene TIA1 and amyotrophic lateral sclerosis.