Network‐based analysis of the resulting PPI network highlighted 15 hub genes, including TOP2A, RRM2, NCAPG, BUB1B, CENPU, CENPF, AURKA, TPX2, MKI67, BIRC5, CDCA5, NUSAP1, EZH2, ECT2, and TK1, as key regulatory elements potentially involved in PCa pathogenesis. Here, NUSAP1 is linked to posterior cortical atrophy.