Network‐based analysis of the resulting PPI network highlighted 15 hub genes, including TOP2A, RRM2, NCAPG, BUB1B, CENPU, CENPF, AURKA, TPX2, MKI67, BIRC5, CDCA5, NUSAP1, EZH2, ECT2, and TK1, as key regulatory elements potentially involved in PCa pathogenesis. This evidence concerns the gene CENPU and posterior cortical atrophy.