Other important entities include superficial leiomyomas expressing SMA and Desmin, Neurotized Melanocytic nevi with melanocytic markers, ganglioneuromas demonstrating S100 in Schwann cells and synaptophysin in ganglion cells, Plexiform Fibrohistiocytic tumors with SMA positivity and S100 negativity, and Desmoplastic Melanomas, which show S100 and SOX10 positivity along with dermal scarring and cytologic atypia. The gene discussed is DES; the disease is melanoma.