Functionally, TCOF1 (Treacle) is involved in ribosome biogenesis, mitotic progression, and DNA damage response (Grzanka and Piekiełko-Witkowska, 2021), and also functions as a prognostic marker in triple-negative breast cancer (Hu et al., 2022). The gene discussed is TCOF1; the disease is triple-negative breast carcinoma.