However, genetically predicted high PD-L1 expression specifically in CD14- CD16+ monocytes was significantly associated with a reduced risk of early TB progression (OR = 0.9184, 95% CI: 0.8460-0.9970, PIVW = 0.0421), consistent across four additional MR models (Figure 3, and Supplementary Figure 1A, B). This evidence concerns the gene CD14 and tuberculosis.