RUNX3 and cancer: Of these, the highest activity was detected by Cebpd, a transcription factor that regulates multiple genes related to hypoxia response in Glioblastoma and other cancers and developing organs, and has been linked to ECM modifications via Egfr/PI3K signaling (162) and the DNA methyltransferase Dnmt3b (148) showed moderate activity but low expression similar to Runx3, HoxA9 and Twist2 (Fig. 4C).