Interestingly, hypoxia and glycolysis related regulators were highlighted for their consistent canonical activity in several cell types: Hif1a was detected in both the non-neural ectoderm as well as the ventral neural tube, which also showed high activity of Ybx1, a multifunctional DNA and RNA binding protein, which directly binds to Hif1a mRNA to stabilize it under hypoxia in hepatocellular cancer cells (115, 182). This evidence concerns the gene HIF1A and hepatocellular carcinoma.