NCOR2 and melanoma: The analysis also revealed epigenetic modifier genes for neural crest formation like Ssrp1, the nucleosome reorganizer and component of FACT (85), and the component of the SMRT co-repressor complex Ncor2 that recruits histone de-acetylases (55), which was previously identified to be downregulated in murine neural crest cultures in response to RA signaling (80), and the nuclear receptor Nr2f2, which regulates neural crest transition to ectomesenchyme in zebrafish and is involved in melanoma metastasis (86, 87).