Of these, the highest activity was detected by Cebpd, a transcription factor that regulates multiple genes related to hypoxia response in Glioblastoma and other cancers and developing organs, and has been linked to ECM modifications via Egfr/PI3K signaling (162) and the DNA methyltransferase Dnmt3b (148) showed moderate activity but low expression similar to Runx3, HoxA9 and Twist2 (Fig. 4C). This evidence concerns the gene EGFR and glioblastoma.