Additionally, Sfpq, which is a RNA splicing protein the loss of which is shown to cause CNS and neural crest defects in zebrafish (88) and Smarcc1 (aka Baf155, Srg3), a core component of the SWI/SNF chromatin remodeling complex, depletion of which is linked to hydrocephalus (89), was highly expressed and canonically active through all stages of neural crest development. This evidence concerns the gene SMARCA1 and Hydrocephalus.