Further mapping demonstrated that many of these NoAD-specific links (e.g., THSD7B-chr2:136665698–136666198, chr2:136874242–136874742 and chr2:137339039–137339539) overlap with distal enhancer-like signature candidate cis-regulatory elements (cCREs-dELS) [31], consistent with its down-regulation in AD given enhancer loss. The gene discussed is THSD7B; the disease is Alzheimer disease.