The ‘liver neoplasms’ CTD over-representation (Fig. 5A) could be attributed to cell cycle-related pathway enrichment and corresponding genes (cell cycle: PDS5A, ORC6, RAD21, ZBTB17; Thyroid cancer: CTNNB1, RET; see Table S5) identified from our CRIPSR screens. This evidence concerns the gene ORC6 and thyroid cancer.