Across disorders, VIP and MGE-derived interneurons show shared disease enrichment with the cortical classes highlighted in these studies, whereas PTSD and MDD exhibit more selective associations with GPe-NDB-SI LHX6-LHX8-GBX1 GABA interneurons and subsets of dopaminergic neurons, pointing to candidate BG microcircuits for distinct components of affective and stress-related risk. The gene discussed is GBX1; the disease is major depressive disorder.