KEGG pathway analysis revealed that 2D Doxo-sensitive genes were enriched for ABC transporters (hsa02010), Alcoholic liver disease (hsa04936), Glycosphingolipid biosynthesis (hsa00601), and Fatty acid biosynthesis (hsa00061) (Fig. 4A), whereas 2D Doxo-resistant genes were enriched for Nicotinate and nicotinamide metabolism (hsa00760), Basal transcription factors (hsa03022), and ABC transporters (hsa02010) (Fig. 4B). Here, ABCG2 is linked to alcoholic liver diseases.