In addition to manifestations listed above, NS patients may experience short stature, autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD)10–13, gastrointestinal problems14, etc. The genetic etiology of NS is heterogeneous and most commonly results from mutations in PTPN11, SOS1, KRAS, and RIT1 genes9. This evidence concerns the gene KRAS and attention deficit-hyperactivity disorder.