MAPK1 and Anxiety: While Mapk1 mutant mice performed similarly to wildtypes in tests of motor function (e.g. open field locomotor activity, home cage activity monitoring, sucrose splash test; Supplementary Figure 7 A–B, Figure 1I), anxiety-like behavior (marble burying assay, dark/light box; Supplementary Figure 7C–D), short term memory (novel object recognition; Supplementary Figure 7E), and associative learning (contextual fear conditioning; Supplementary Figure 7F), unique phenotypes were identified.