Furthermore, the exposure of cultured neuroblastoma and glial cells to recombinant TTR oligomers is associated with cytotoxicity (Sousa, Cardoso et al. 2001, Sousa and Saraiva 2001, Andersson, Olofsson et al. 2002, Reixach, Deechongkit et al. 2004, Sorgjerd, Klingstedt et al. 2008, Dasari, Hughes et al. 2019), suggesting that TTR internalization could negatively impact the cell. This evidence concerns the gene TTR and neuroblastoma.