Specifically, A-to-I RNA editing of cytochrome P450 family 1 subfamily A member 1 (CYP1A1) enhances the nuclear translocation of heme oxygenase-1(HO-1) by activating the PI3K/Akt pathway, thereby increasing the resistance of NSCLC cells to oxidative stress [385]. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.