ALCL is a distinct subtype of T cell NHL, first recognised by Stein et al. (1985) and later classified by the WHO as a CD30-positive T cell neoplasm characterised by large anaplastic lymphoid cells with pleomorphic nuclei and strong CD30 (Ki-1) expression [2]. The gene discussed is TNFRSF8; the disease is T-cell and NK-cell neoplasm.