In addition, we plan to pre-intervene in the PI3K/Akt signaling pathway in the cTnI193His-M model and observe the changes in glucose and lipid metabolism and the incidence of RCM, with the aim of elucidating the role of these alterations in cTnIR193H mutation-induced RCM. The gene discussed is AKT1; the disease is cardiomyopathy, familial restrictive, 1.