Ad5/3-E2F-d24-HIL7 (TILT-517) was engineered with a chimeric fiber to target renal cancer cells, an E2F promoter driving viral E1A, Δ24 deletion in the E1A gene, Δ145 deletion in the E1B-19K gene, and a hIL-7 transgene. The gene discussed is DHTKD1; the disease is renal carcinoma.