DSG2 and hereditary clear cell renal cell carcinoma: In contrast, renal cell carcinomas (RCCs) express high levels of CD46 (Nagaya et al., 2012; Fang et al., 2016; Guse et al., 2007) and desmoglein-2 (DSG2), the primary cellular receptors for several subgroup B adenoviruses, most notably Ad35 (Gaggar et al., 2003) and Ad3 (Wang et al., 2011).