Multivariable analysis (sample size adequacy: N = 1,953) demonstrated independent mortality associations for STS-PROM (HR = 1.06, 95% CI: 1.02–1.11; P = 0.003), stroke (HR = 3.30, 95% CI: 1.29–8.43; P = 0.013), stage 3 AKI (HR = 9.19, 95% CI: 3.63–23.27; P < 0.001), and discharge albumin (HR = 0.88, 95% CI: 0.83–0.94; P < 0.001). The gene discussed is ALB; the disease is Stroke.