The intramolecular disulfide-crosslinking was used to cross-link the HSA NPs to promote redox-responsive drug release and surface-functionalize using Substance P (SP) peptide as a targeting ligand to neurokinin-1 (NK-1) receptors overexpressed on both glioma cells and brain endothelial cells (Fig. 11A). This evidence concerns the gene ALB and central nervous system cancer.