HLA-E and acute myeloid leukemia: In line with this finding, HLA-E was highly correlated with AHR (p<0.0001) in the Beat AML dataset, previously found to be a driver of monocytic maturation in AML (25, 26) (p<0.0001) (Figure 2D) as well as in the TCGA dataset (High vs Low: 0.69; 0.272-1.11 95% CI; Pval: 0.00207; Welchs T-test) (Supplementary Figure 4C).