BTRC and hepatocellular carcinoma: One example is the β-catenin-370aa protein translated from circ-0004194, which promotes HCC malignancy through the Wnt/β-catenin pathway by acting as bait for GSK3β (Glycogen Synthase Kinase 3 Beta), which is responsible for β-catenin ubiquitination and degradation with the ubiquitin ligase β-TrCP (Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase) (55).