SMURF1 and hepatocellular carcinoma: CircCCNY, or hsa_circ_0000235, enhances HCC sensitivity to Lenvatinib and suppresses immune evasion by serving as a scaffold for binding HSP60 and the E3 ubiquitin ligase SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1), leading to degradation and inactivation of the MAPK signaling pathway (40).