GPC3 and hepatocellular carcinoma: A recent meta-analysis of 82 studies, including a total of 15,024 patients, confirmed that circRNAs in combination with mRNAs-specifically hsa_circ_000224, hsa_circ_0003998, KIAA0101 mRNA, and GPC-3 (Glypican 3) mRNA-are optimal diagnostic liquid biopsy-based biomarkers for HCC (14).