Known CAR-T target for the treatment of HCC include Glypican 3 (GPC3) (89, 90), CD133 (112, 113), hepatocyte growth factor receptor (HGFR) (114), NKG2D (115), CD147 (116), alpha fetoprotein (AFP) (117), C-X-C Motif Chemokine Receptor 2 (CXCR2) (118), and CD39 (119, 120). This evidence concerns the gene GPC3 and hepatocellular carcinoma.