Another study developed a novel approach by synthesizing circDNA and circRNA with miRNA sponge-like functions for several oncogenic miRNAs that target different tumor suppressor genes, such as ANGPTL1 (Angiopoietin Like 1), SOCS3 (Suppressor Of Cytokine Signaling 3), and EHHADH (Enoyl-CoA Hydratase And 3-Hydroxyacyl CoA Dehydrogenase). This evidence concerns the gene ANGPTL1 and neoplasm.