Compressed macrophages were also enriched in a GAM signature related to hypoxia response (Hypoxia-GAM), with upregulation of hypoxia-related genes Adm and Bnip3. Patients with a higher proportion of these Hypoxia-GAMs are reported to have reduced overall survival, and patients with increased Adm expression had poorer response to chemotherapy, suggesting a tumor-supportive role (72). This evidence concerns the gene BNIP3 and neoplasm.