Promote cancer stem cell (CSC)-like cell formation (26)(In Vitro);Promote the migration and invasion of tumor cells and participate in chemotherapy-induced EMT (73)(Ex Vivo);Aggregate regulatory T cells (FoxP3+ T cells) in tumor tissues; Establish communication with CD4+/CD8+ T cells and B cells, regulate lymphocyte recruitment and anti - tumor immunity (74)(Ex Vivo). This evidence concerns the gene CD4 and cancer.