CXCR4 and lung adenocarcinoma: Studies have shown that CCR6/CCL20 drives proliferation and migration in lung adenocarcinoma via autocrine/paracrine mechanisms (24, 25), while the CXCL12/CXCR4 axis promotes OSCC invasion and distant metastasis—with CXCR4 blockade reducing lymph node metastasis (26, 27).