Activate tumor-associated macrophages (TAMs), induce M2 polarization and secrete epidermal growth factor (EGF) (63)(In Vitro);Promote the transformation of normal fibroblasts (NOFs) into cancer-promoting cancer-associated fibroblasts (CAFs) (62)(In Vitro);Promote tumor invasion and migration (61)(In Vitro);Promote tumor recurrence (66)(Ex Vivo). This evidence concerns the gene EGF and neoplasm.