(On the one hand, OSCC cells activate the expression and release of matrix metalloproteinases MMP-2, MMP-3, MMP-9 by binding chemokines such as CXCL8, CXCL10, and CXCL16 to receptors CXCR1/2, CXCR3, and CXCR6, respectively, breaking the dynamic balance of the extracellular matrix and degrading ECM to open up a path for tumor invasion and metastasis. This evidence concerns the gene MMP9 and neoplasm.