In a study on CXCL1 promoting the mutual activation of cancer-associated fibroblasts and OSCC cells, the results showed that CXCL1 neutralizing antibody and CXCR2 antagonist SB225002 attenuated the invasion-promoting effect of CAF-CM, confirming the importance of CXCL1 in tumor invasion (61). Here, CXCR2 is linked to cancer.