For example, senescent fibroblasts in synovial tissue of patients with rheumatoid arthritis secrete interleukin-6 (IL-6), interleukin-8 (IL-8), and matrix metalloproteinases (MMPs), sustaining inflammation, recruiting immune cells, and contributing to joint destruction (34, 76) This secretory profile undermines resilience by impairing tissue architecture, promoting chronic inflammation, and disrupting regenerative niches. This evidence concerns the gene CXCL8 and rheumatoid arthritis.