In our cohort, patients with severe COVID-19 exhibited higher viremia than those with mild or moderate disease at the first extraction, and these elevated levels persisted at the second sampling (Supplementary Figure S2).When evaluating the effect of viremia levels in gene expression, a negative correlation was found between viremia and TLR7 levels, while there was a tendency for OAS1 to show increased expression in patients with higher viremia (Supplementary Table S5). Here, TLR7 is linked to COVID-19.