High TICRR expression correlated with activation of EMT, E2F, G2/M checkpoint and PI3K/AKT/mTOR pathways (16), and TICRR knockdown reduced malignant phenotypes—findings that align with recent studies showing TICRR can potentiate PI3K/AKT/mTOR signaling and thereby enhance tumor aggressiveness and immune infiltration in other tumor contexts (24). This evidence concerns the gene AKT1 and neoplasm.