Overactive NF‐kB pathway of lymphomas of this region, 9p24.1 aberration, and prevalence of programmed death ligand (PD‐L1)–expressing lymphocytes and macrophages in the tumor microenvironment are the main molecular and cellular features, distinguishing lymphomas of these regions from other lymphomas [19]. The gene discussed is NFKB1; the disease is lymphoma.