HEPACAM and autoimmune disease: MS is the autoimmune disease for which EBV is most strongly implicated as a necessary environmental factor, and both tissue and cell specificity of EBV regulation further align with MS-specific immunobiology in which memory B cells drive CNS infiltration.59 Moreover, it has been clearly demonstrated that the EBV virus harbors sequences that are cross-reactive with myelin epitopes including GlialCAM that are likely also playing a critical role in the pathogensis of MS18,19.