LRRK2 and Parkinson disease: The most frequent were GBA1 variants rs75548401 (p.T408M) and rs76763715 (p.N409S), which are known to have higher frequencies in European populations compared to African populations.39 Rare variants in LRRK2 and PINK1 were also identified, several of which have been proposed as familial causes of PD and are predicted to alter kinase function.40,41 Variants in PRKN, PLA2G6, POLG, and SYNJ1 were observed at low frequencies, with in-silico tools supporting pathogenic classifications.