For individuals diagnosed <7 years, we observed significant associations at MHC (lead SNP: rs3873448, P=2.23×10−242), INS (lead SNP: rs3842753, P=1.87×10−59), PTPN22 (lead SNP: rs2476601, P=2.14×10−30), and LINC01882 (lead SNP: rs67878610, P=1.64×10−11), all of which have been previously reported in association with type 1 diabetes (24). This evidence concerns the gene INS and type 1 diabetes mellitus.