KCNQ1 and Arrhythmia: Discordant variants (MAVE normal function but AlphaMissense strong pathogenic) had a RR of 73.3 (59.4–90.5; 3.7-fold lower than concordant pathogenic variants), suggesting that while these variants collectively retain some arrhythmia risk, AlphaMissense overcalls KCNQ1 variant pathogenicity or identifies variants with smaller-effect or lower-penetrance.