Abnormal neuronal firing may arisefrom, or be worsened by, mutated ion channels, such as Nav1.1 in DS.One mutated channel not only affects its own permeant ion, but also,overall elemental distribution, as neural tissue ionic equilibriumis finely controlled., Different types of epilepsy areprofoundly associated with elemental imbalance, since changes in the concentration of one ion can affectothers. Here, SCN1A is linked to Dravet syndrome.