Reportson copper serum levels in epilepsy patients reveal that the use ofanticonvulsant drugs, such as phenobarbital, might mask actual copperlevels in brain tissue. Therefore, dataon DS should be interpreted taking into consideration that studiesinvolving patients under treatment and iPS-based studies might presentdivergences when considering micronutrients’ bioavailability.In addition, copper has an inhibitory effect on GABA receptors andon A-type potassium channels, which mightcontribute to further explaining potassium elevated levels found inDS neural induced EBs (Figure D). The gene discussed is KCNA4; the disease is epilepsy.