GSVA results revealed that seven cell types in control group were mainly enriched into metabolism of serotonin, transfer of LPS from LBP carrier to CD14 and so on, while cell types in CRC group were mainly enriched for pathways such as PAOs oxidize polyamines to amines, FGFR1c and Klotho ligand binding and activation, and COX reactions (Fig. 2A, B). Here, KL is linked to colorectal carcinoma.