Thus, our preliminary neuropathological assessment across FTLD-tau subtypes (with co-occurring TDP-43 pathologies) may help initiate a broader discussion on the potential link between insulin dysfunction and the increased presence of 4-repeat tau isoforms in these cases, a hypothesis further supported by the detection of insulin in CNS tissue from CBD patients with T2DM. The gene discussed is MAPT; the disease is type 2 diabetes mellitus.