Among the haplotypes present in this RA sub-cohort, the haplotype HLA-A*02 ~ HLA-B*39.1 ~ HLA-C*07 ~ HLA-DRB1*14:02 was shown to be the most frequently distributed, representing 10.0%, followed by the haplotypes HLA-A*02 ~ HLA-B*39.1 ~ HLA-C*07 ~ HLA-DRB1*04:01 and HLA-A*24 ~ HLA-B*39.1 ~ HLA-C*07 ~ HLA-DRB1*14:02 with 3.3% each (result not shown). The gene discussed is HLA-A; the disease is rheumatoid arthritis.