ROBO1 and early-onset autosomal dominant Alzheimer disease: Finally, given the concerns about the developmental origins of disease, it is provocative that two of the genes that show differential expression between preeclamptic and control placentas in males, COL6A3 [78] and ROBO1 [79, 80], also have been associated with risk for Alzheimer’s disease, which is now believed to have a vascular component [81].