While direct empirical support in late-onset preeclampsia is still emerging, we hypothesise that dysregulation of ADAMTS12, an ECM remodelling enzyme, may impair tissue remodelling, trophoblast invasion, and spiral artery remodelling, even in the absence of overt vascular pathology, and this ECM dysfunction may be relevant in late-onset preeclampsia [97]. Here, ADAMTS12 is linked to preeclampsia.