VCAN and hypertensive disorder: Other significantly differentially expressed genes included Cadherin 13 (CDH13) and Insulin Like Growth Factor Binding Protein 7 (IGFBP7), both involved in vascular remodelling and angiogenesis [43, 44], as well as extracellular matrix components Collagen Type VI Alpha 3 Chain (COL6A3), integral in collagen organising matrix components and associated with hypertension [45] and Versican (VCAN), which plays critical roles in placental development including trophoblast migration and invasion [46].