Finally, given the concerns about the developmental origins of disease, it is provocative that two of the genes that show differential expression between preeclamptic and control placentas in males, COL6A3 [78] and ROBO1 [79, 80], also have been associated with risk for Alzheimer’s disease, which is now believed to have a vascular component [81]. The gene discussed is ROBO1; the disease is Alzheimer disease.