This conserved arsenal includes a set of unique genes implicated in host adaptation: vat (vacuolating autotransporter toxin, enhancing sepsis fitness [62]), hcp2/clpV (T6SS components, mediating bacterial competition [63, 64]), and neuABCD/kpsT (enabling K1 capsule biosynthesis and conferring serum resistance [65, 66]). The gene discussed is CYCSP52; the disease is Sepsis.