However, in notable contrast with NorNB and aRMS, where SE-associated TFs were readily identified among their respective top ten DepMap dependencies (PHOX2A/B, HAND2, GATA3 for NorNB and MYOD1, MYOG for aRMS) (Fig. 1G, H), in Ewing sarcoma, none of the top ten dependencies were SE-associated TFs, despite a similar representation of TFs across all three entities (Supp. This evidence concerns the gene HAND2 and Ewing sarcoma.