For example, in alveolar rhabdomyosarcoma (aRMS), the fusion oncogene PAX3::FOXO1 (or PAX7::FOXO1) binds SEs together with other MTFs, including MYOD, MYOG, and MYCN, to sustain proliferation, and their depletion leads to altered proliferation and cell death33,34. Here, PAX7 is linked to alveolar rhabdomyosarcoma.