For example, in alveolar rhabdomyosarcoma (aRMS), the fusion oncogene PAX3::FOXO1 (or PAX7::FOXO1) binds SEs together with other MTFs, including MYOD, MYOG, and MYCN, to sustain proliferation, and their depletion leads to altered proliferation and cell death33,34. The gene discussed is PAX3; the disease is alveolar rhabdomyosarcoma.