However, whether it can inhibit the TMEM16A chloride channel in lung adenocarcinoma cells requires further investigation in the future.However, it must be borne in mind that this study is limited to SH’s anti-tumor effects on lung adenocarcinoma, lacks animal safety testing, is slightly limited in terms of the in vitro experimental cell types, and lacks exploration of the action sites of SH regulating Hedgehog pathway. Here, ANO1 is linked to lung adenocarcinoma.