Plasmids containing the MHCII-targeted vaccine format encode a bivalent fusion protein comprising (i) a targeting unit consisting of a mAb-derived single chain fragment variable (scFv) specific for either mouse MHCII (I-Ed) molecules or human leukocyte antigen class II (HLAII) molecules, (ii) a dimerization unit derived from the hinge and CH3 domain of human IgG3, and (iii) an antigenic unit consisting of influenza HA from influenza A/Shanghai/2/2013 (H7N9) (HS)5,8. Here, IGHG3 is linked to influenza.