CD274 and neoplasm: miRNA-Trapping by RNA affinity purification (miTRAP) in ES-2 cell lysates confirmed IGF2BP1 binding to the PD-L1 3’UTR and identified tumor-intrinsic miRNAs, including the miR17-92 family—known PD-L1 regulators43—enriched in C5-HGSC (Supplementary Fig. S5b).