Additionally, in vitro analyses of GC cell lines (MGC803, HGC27, SGC7901, and MKN45) revealed significantly reduced ALDH3A2 mRNA and protein levels compared with the normal gastric epithelial cell line GES-1 (Fig. 1J, K), suggesting a potential tumor-suppressive role of ALDH3A2 in contributing to GC progression. Here, ALDH3A2 is linked to gastric cancer.