In glioblastoma and squamous cell carcinoma (SCC), abnormal regulation of ALDH3A1 enzymatic activity sensitized tumor cells to ferroptosis through enhanced lipid peroxidation, and a selective enzymatic activity inhibitor of ALDH3A1 (ALDH3A1-EN40) significantly increased ferroptosis sensitivity, thereby suppressing SCC cell proliferation and tumor growth [62]. This evidence concerns the gene ALDH3A1 and glioblastoma.