After confirming the liver accumulation of insulindelivered bycasNP/insulin/C10, we next investigated whether casNP/insulin/C10 could overcome the risk of hypoglycemia under fasting conditions.Diabetic mice were fasted overnight before receiving casNP/insulin/C10 at 50 IU/kg body weight orally or IAsp at 5 IU/kg body weights.c., respectively. Here, INS is linked to Hypoglycemia.