In CD4+ naïve/central‐memory T cells (Figure 4B), higher GSDMB expression was associated with reduced liability for AS, Crohn's disease, rheumatoid arthritis, and UC, whereas PSC showed the opposite direction; the lineage‐level pooled estimate favored protection in direction but did not reach significance (pooled OR = 0.82, 95% CI 0.67–1.01; I2 = 86%). This evidence concerns the gene CD4 and Crohn disease.