In CD4+ naïve/central‐memory T cells and CD8+ effector‐memory T cells, expression was protective in AS, CD, RA, and UC yet risk‐enhancing in PSC; in contrast, genetically predicted GSDMB expression in S100B+ CD8+ T cells showed no significant association with any of the eight diseases. This evidence concerns the gene GSDMB and rheumatoid arthritis.