In immature/naïve B cells (Figure 4A), higher GSDMB expression was associated with protection in Crohn's disease (OR = 0.67, 95% CI 0.53–0.84) but increased risk in BD (OR = 3.43, 95% CI 1.06–11.02); the pooled estimate across traits in this lineage was not statistically significant (pooled OR = 0.89, 95% CI 0.77–1.03). Here, GSDMB is linked to Crohn disease.