The analysis, based on single‐cell genetic data, shows how GSDMA, GSDMB, and GSDMD affect disease risk in various immune cell types, highlighting distinct protective or risk‐enhancing roles in ankylosing spondylitis (AS), Behçet disease (BD), Crohn disease (CD), hidradenitis suppurativa (HS), primary sclerosing cholangitis (PSC), psoriasis (PsO), rheumatoid arthritis (RA), and ulcerative colitis (UC). Here, GSDMB is linked to rheumatoid arthritis.