Specifically, elevated SEPHS1 expression was associated with reduced OS in adrenocortical carcinoma (HR = 3.462, p < 0.001), liver hepatocellular carcinoma (HR = 2.598, p < 0.001), and skin cutaneous melanoma (HR = 1.503, p < 0.001) (Fig. 4B-E). This evidence concerns the gene SEPHS1 and cutaneous melanoma.