Genes such as BUD23, MARS1, METTL6, METTL2B, LCMT1, AHCY, SEPHS1, and SEPHS2 were consistently upregulated in multiple cancer types, suggesting a broad role in tumor progression, whereas MAT2B, AHCYL1, AHCYL2, GGT7, and PAPSS2 were frequently downregulated, with GGT6 showing pronounced suppression in renal cancers. The gene discussed is PAPSS2; the disease is cancer.