Kaplan–Meier curves based on TCGA data further confirmed that high SEPHS1 expression was linked to significantly lower OS probabilities in adrenocortical carcinoma, invasive breast carcinoma, liver hepatocellular carcinoma, lung adenocarcinoma, skin cutaneous melanoma, and uterine corpus endometrial carcinoma (Fig. 4F). This evidence concerns the gene SEPHS1 and adrenal cortex carcinoma.