Moreover, acute pancreatitis-associated deaths were more frequently reported among patients characterized by higher serum levels of creatinine (3.7 mg/dL ± 2.6 vs. 1.5 mg/dL ± 1.4, p = 0.05; Appendix A, Table A5), diagnosis of ANP (i.e., 75.0% of deaths vs. 29.0% of hospital discharges, Figure 2), signs of multiorgan failure (75.0% vs. 17.7%, p = 0.002), respiratory failure (75.0% vs. 9.7%, p < 0.001), higher CTSIs (7.2 ± 3.3 vs. 4.3 ± 2.3, p = 0.016), and collections (85.5% vs. 35.5%, p = 0.015). This evidence concerns the gene NPPA and respiratory failure.