YPEL3 and breast neoplasm: Also, YPEL3, a downstream effector of p53, has been suggested to function as a tumor suppressor by inducing senescence in breast tumor cells [55], and by suppressing epithelial to mesenchymal transition (EMT) and tumor metastasis by targeting Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells [56].