LRRC15 and ovarian carcinoma: In ovarian cancer models, LRRC15 expression inhibited anoikis and promoted metastasis, which was suppressed by the LRRC15-targeted ADC ABBV-085 [199] Single-cell RNA sequencing of over 600 patient samples revealed that tumors with abundant LRRC15+ CAFs demonstrated poor response to anti-PD-L1 immunotherapy, highlighting their immunosuppressive role [46].