Physical Tumor Microenvironment: CAFs are central in remodeling the ECM by producing collagens, fibronectin, and hyaluronic acid, leading to desmoplasia which is a stiff, fibrotic stroma that elevates interstitial pressure, enhances mechanotransduction, and facilitates tumor invasion and epithelial-to-mesenchymal transition (EMT) through integrin and focal adhesion signaling [16,17]. The gene discussed is FN1; the disease is neoplasm.